Injectable polymeric hydrogels for the delivery of therapeutic agents: A review
Since drug delivery systems have become one of the most promising areas of human health
related research, the applications of biomaterials such as hydrogels have been widely
investigated. Possessing unique hydrophilic, biocompatible network structures and the
ability to form solid-like gel states once administered, injectable hydrogels facilitate the
encapsulation and release of therapeutic agents, including drugs, proteins, genes and cells,
in a controllable manner. A wide and diverse range of techniques have been used to
generate hydrogels, from chemical cross-linking, such as photo-polymerization, click
chemistry, enzyme-catalyzed reactions, Schiff’s base reactions, and thiol-based Michael
reactions, to physical cross-linking induced by temperature, pH, ionic interaction, guest–
host inclusion, stereo-complexation or complementary binding. This review covers the
utilization of various injectable hydrogel systems for the delivery of therapeutic agents
from the viewpoint of cross-linking methods.
| Title: | Injectable polymeric hydrogels for the delivery of therapeutic agents: A review |
| Authors: | Nguyen, Quang Vinh Huynh, Dai Phu Park, Jae Hyung |
| Keywords: | Injectable;Biomaterials;Cross-linked hydrogel;Controlled release;Delivery system |
| Issue Date: | 2015 |
| Publisher: | Đại học Quốc gia Hà Nội |
| Citation: | ISIKNOWLEDGE |
| Abstract: | Since drug delivery systems have become one of the most promising areas of human health related research, the applications of biomaterials such as hydrogels have been widely investigated. Possessing unique hydrophilic, biocompatible network structures and the ability to form solid-like gel states once administered, injectable hydrogels facilitate the encapsulation and release of therapeutic agents, including drugs, proteins, genes and cells, in a controllable manner. A wide and diverse range of techniques have been used to generate hydrogels, from chemical cross-linking, such as photo-polymerization, click chemistry, enzyme-catalyzed reactions, Schiff’s base reactions, and thiol-based Michael reactions, to physical cross-linking induced by temperature, pH, ionic interaction, guest– host inclusion, stereo-complexation or complementary binding. This review covers the utilization of various injectable hydrogel systems for the delivery of therapeutic agents from the viewpoint of cross-linking methods. |
| Description: | EUROPEAN POLYMER JOURNAL Volume: 72 Pages: 602-619 Published: NOV 2015 ; TNS05556 |
| URI: | http://repository.vnu.edu.vn/handle/VNU_123/27075 |
| Appears in Collections: | Bài báo của ĐHQGHN trong Web of Science |
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